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Anti-GRIA2 PHOSPHO Antibody EP929Y
Also for GRIA2 (NM_000826)
|A synthetic phospho-peptide corresponding to residues surrounding Ser880/891 of human GluR2/3 was used as immunogen. The antibody detects both GluR2/3 phosphorylated on Serine 880/891 of the mature human, and also unphosphorylated Glur-2/3.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:5000; IP: 1:100; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt.
|Homo sapiens glutamate receptor, ionotropic, AMPA 2 (GRIA2), transcript variant 1|
|GluA2; GluR-K2; GLUR2; GLURB; HBGR2|
Entrez Gene 2891 Human
Entrez Gene 14800 Mouse
Entrez Gene 29627 Rat
|Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq]. |
|TransmembraneIon Channels: Glutamate ReceptorsDruggable Genome Neuroactive ligand-receptor interactionLong-term potentiationLong-term depressionAmyotrophic lateral sclerosis (ALS)|
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Western blot - GluR2 + 3 antibody [EP929Y]; Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] at 1/5000 dilution + human brain lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 98 kDa.Observed band size : 98 kDa.
Immunohistochemistry (Paraffin-embedded sections) - GluR2 + 3 antibody [EP929Y]; TA303528 at 1/100 dilution staining GluR2 +3 in human brain by Immunohistochemsitry, Paraffin embedded tissue.