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Anti-PTK2B Antibody EP206Y
Also for PTK2B (NM_173174)
|A synthetic peptide corresponding to residues on the C-terminus of human FAK2 was used as an immunogen.|
|Rat, Human (Does not react with: Mouse)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:2000; IHC-P: 1:100 - 1:250; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt or ICC/IF.
|Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 1|
|CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK|
Entrez Gene 2185 Human
Entrez Gene 50646 Rat
|This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]. |
|Protein KinaseDruggable Genome Calcium signaling pathwayChemokine signaling pathwayNatural killer cell mediated cytotoxicityLeukocyte transendothelial migrationGnRH signaling pathway|
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Western blot - PYK2 antibody [EP206Y]; All lanes : Anti-PYK2 antibody [EP206Y] at 1/2000 dilution.Lane 1 : Human brain lysate.Lane 2 : Rat brain lysate.Lane 3 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 116 kDa.Observed band size : 116 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PYK2 antibody [EP206Y]; Immunohistochemical analysis of paraffin-embedded human brain using TA303509 at 1/100 dilution.