Anti-PTK2B Antibody, E354

Also for PTK2B (NM_173174)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in C-terminus of rat Pyk2 was used as immunogen. The antibody does not cross-react with other Fak family members.
Clone Name	E354	Isotype	Rabbit IgG
Species Reactivity	Human, Rat	Concentration
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:500; IP: 1:50
Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 1
Alternative Name	CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK
Database Link	NP_775266
Function	This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq].
Related Pathway	EGFR1 Signaling Pathway

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WB Image

Western blot analysis on Jurkat cell lysate using anti-Pyk2 (C-term) RabMAb (TA303507), dilution 1:500.

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Anti-PTK2B Antibody E354

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data