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Anti-ERBB3 PHOSPHO Antibody EPR2325


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SKU Description Amount Price Availability*  
TA303500 Rabbit monoclonal antibody against HER3/ErbB3 Phospho (pY1289) (EPR2325 ) (phospho-specific) 100ul $325 In Stock
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Also for ERBB3 (NM_001982)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding Tyrosine 1289 of human HER3/ErbB3 was used as an immunogen. The antibody only detects HER3/ErbB3 phosphorylated on Tyrosine 1289.
Clone NameEPR2325 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:2500 - 1:5000; ICC/IF: 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target Nameerb-b2 receptor tyrosine kinase 3
Alternative NameErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3
Database LinkNP_001973
Entrez Gene 2065 Human
FunctionThis gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq].
Related PathwayProtein KinaseSecreted ProteinTransmembraneStem cell - PluripotencyAdult stem cellsDruggable Genome ErbB signaling pathwayCalcium signaling pathwayEndocytosis

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - ErbB 3 (phospho Y1289) antibody [EPR2325]; All lanes : Anti-ErbB 3 (phospho Y1289) antibody [EPR2325] at 1/5000 dilution.Lane 1 : SKBR3 cell lysate untreated.Lane 2 : SKBR3 cell lysate treated with Neuregulin .Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 148 kDa.Observed band size : 185 kDa .

IF Image
Immunocytochemistry/ Immunofluorescence - ErbB 3 (phospho Y1289) antibody [EPR2325]; Immunofluorescent staining of MCF7 cells using TA303500 at 1/100 dilution.


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