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Anti-CRKL PHOSPHO Antibody EP270Y


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SKU Description Amount Price Availability*  
TA303464 Rabbit monoclonal antibody against Phospho CrkL (pY207)(EP270Y) (phospho-specific) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human CrkL was used as immunogen. The antibody only detects CrkL phosphorylated on Tyrosine 207.
Clone NameEP270Y IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:50000; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens CRK like proto-oncogene, adaptor protein (CRKL)
Alternative Namev-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Database LinkNP_005198
Entrez Gene 1399 Human
Entrez Gene 12929 Mouse
FunctionThis gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Related PathwayDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwayFocal adhesionFc gamma R-mediated phagocytosisNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CrkL antibody [EP270Y]; All lanes : Anti-CrkL (phospho Y207) antibody [EP270Y] at 1/50000 dilution.Lane 1 : (A) K562 cell lysates untreated.Lane 2 : (B) K562 cell lysates treated with AP.Lysates/proteins at 10 ug per lane.Predicted band size : 34 kDa.Observed band size : 37 kDa .


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