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Anti-CCR5 Antibody E164


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA303455 Rabbit monoclonal antibody against CCR5/CKR5(E164) 100ul $325 In Stock
LC424630 CCR5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in C-terminus (cytoplasmic domain) of human CKR5 was used as immunogen. The antibody does not cross-react with other G-protein coupled receptor 1 family members.
Clone NameE164 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsFC: 1:20; WB: 1:2000; IHC-P: Use at an assay dependent concentration
Predicted MW Explanation 41 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Is unsuitable for ICC or IP.

Reference Data

Target NameHomo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant A
Alternative NameCC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; IDDM22
Database LinkNP_000570
Entrez Gene 1234 Human
Entrez Gene 12774 Mouse
Entrez Gene 117029 Rat
FunctionThis gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Related PathwayGPCRES Cell Differentiation/IPSTransmembraneDruggable Genome Cytokine-cytokine receptor interactionChemokine signaling pathwayEndocytosis

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - CCR5 antibody [E164]; All lanes : Anti-CCR5 antibody [E164] at 1/2000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : K562 cell lysate.Lane 3 : Daudi cell lysate.Predicted band size : 41 kDa.Observed band size : 60 kDa .


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