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Anti-CCR3 Antibody Y31
Also for CCR3 (NM_178329)
|A synthetic peptide corresponding to residues in C-terminal cytoplasmic domain of human CKR3 was used as immunogen. Predicted to cross-react with macaque, based on sequence homology.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500; IHC: 1:100; ICC: 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Protein A purified
|Homo sapiens chemokine (C-C motif) receptor 3 (CCR3), transcript variant 2|
|CC-CKR-3; CD193; CKR3; CMKBR3|
|The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]. |
Cytokine-cytokine receptor interaction
Signaling by GPCR
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Western blot - CCR3 antibody [Y31]; All lanes : Anti-CCR3 antibody [Y31] at 1/500 dilution.Lane 1 : K562 cell lysate.Lane 2 : Daudi cell lysate.Predicted band size : 43 kDa.Observed band size : 60 kDa .
Immunohistochemistry (Paraffin-embedded sections) - CCR3 antibody [Y31]; Immunohistochemical analysis of paraffin-embedded human liver tissue using TA303454 at 1/100 dilution.