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Anti-CCR3 Antibody Y31

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303454
  • Rabbit monoclonal antibody against CCR3/CKR3 (C-term)(Y31)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC405966) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in C-terminal cytoplasmic domain of human CKR3 was used as immunogen. Predicted to cross-react with macaque, based on sequence homology.
Clone NameY31 IsotypeIgG
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 1:100; ICC: 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Protein A purified

Reference Data

Target NameHomo sapiens chemokine (C-C motif) receptor 3 (CCR3), transcript variant 2
Alternative NameCC-CKR-3; CD193; CKR3; CMKBR3
Database LinkNP_847899
FunctionThe protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq].
Related Pathway
Cytokine-cytokine receptor interaction
Signaling by GPCR

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WB Image
Western blot - CCR3 antibody [Y31]; All lanes : Anti-CCR3 antibody [Y31] at 1/500 dilution.Lane 1 : K562 cell lysate.Lane 2 : Daudi cell lysate.Predicted band size : 43 kDa.Observed band size : 60 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - CCR3 antibody [Y31]; Immunohistochemical analysis of paraffin-embedded human liver tissue using TA303454 at 1/100 dilution.

 

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