Homo sapiens cyclin-dependent kinase 2 (CDK2), transcript variant 1
Synonyms:
p33(CDK2)
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding tyrosine 15 of human Cdk2 was used as immunogen. The antibody detects Cdk2 phosphorylated on tyrosine 15.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq].
Related Pathway
Cell cycle
Delta-Notch Signaling Pathway
TGF Beta Signaling Pathway
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Western blot analysis on HeLa cell lysates using anti-Phospho-Cdk2 (pY15) RabMAb (TA303442), 1:50,000 dilution. Cells were either (A) treated (B) untreated with LP.
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