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Anti-CASP2 Antibody Y154
Also for CASP2 (NM_032982)
|A synthetic peptide corresponding to C-terminus of human Caspase-2 p18 subunit was used as immunogen. The antibody should recognize both pro-form (~50kDa) and p18 cleaved-form of Caspase-2. Predicted to detect the splice isoform (35 kDa) based on sequence|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Does not react with Mouse, Rat
|Homo sapiens caspase 2, apoptosis-related cysteine peptidase (CASP2), transcript variant 1|
|CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57|
|This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq]. |
MAPK signaling pathway
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Western blot - Caspase 2 antibody [Y154]; Anti-Caspase 2 antibody [Y154] at 1/500 dilution + Jurkat cell lysate.Predicted band size : 49 kDa.Observed band size : 50 kDa .Additional bands at : 18 kDa (possible cleavage fragment).