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Anti-BCR PHOSPHO Antibody EPR576(2)Y

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA303404 Rabbit monoclonal antibody against Bcr Phospho (pY177) (EPR576(2)Y ) (Phospho-Specific) 100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding tyrosine 177 of human Bcr was used as immunogen.
Clone NameEPR576(2)Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1,000
Predicted MW Explanation 143 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens breakpoint cluster region (BCR), transcript variant 1
Alternative NameALL; BCR1; CML; D22S11; D22S662; PHL
Database LinkNP_004318
Entrez Gene 613 Human
FunctionA reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayProtein KinaseDruggable Genome Pathways in cancerChronic myeloid leukemia

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

 

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