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Anti-BCR PHOSPHO Antibody EPR576(2)Y
|A synthetic peptide corresponding to residues surrounding tyrosine 177 of human Bcr was used as immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens breakpoint cluster region (BCR), transcript variant 1|
|ALL; BCR1; CML; D22S11; D22S662; PHL|
|A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
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Western blot - Bcr (phospho Y177) antibody [EPR576(2)Y]; All lanes : Anti-Bcr (phospho Y177) antibody [EPR576(2)Y] at 1/1000 dilution.Lane 1 : 3T3 cell lysate, membrane un-treated.Lane 2 : 3T3 cell lysate, membrane treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 143 kDa.Observed band size : 153 kDa .