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Anti-BCR Antibody Polyclonal
|A synthetic peptide corresponding to residues in the C-term of human Bcr was used as immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
|WB, IHC, IF
||IHC: 1:100-250; ICC: 1:250-500; IP: 1:40
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Protein A purified (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens breakpoint cluster region (BCR), transcript variant 1|
|ALL; BCR1; CML; D22S11; D22S662; PHL|
|A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
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Western blot - Anti-Bcr antibody; Anti-Bcr antibody at 1/40 dilution + immunoprecipitation pellets from Jurkat cell lysate .Observed band size : 130 kDa .
Immunohistochemistry (Paraffin-embedded sections) - Bcr antibody; Immunohistochemical analysis of paraffin-embedded human lung carcinoma using ab32523 at 1/100 dilution.
Immunocytochemistry/ Immunofluorescence - Bcr antibody; Immunofluorescent staining of HeLa cells using ab32523 at 1/250 dilution.