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Anti-APC Antibody EP701Y


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SKU Description Amount Price Availability*  
TA303394 Rabbit monoclonal antibody against APC (EP701Y) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human APC was used as immunogen. This antibody is predicted to detect isoform 2 based on sequence analysis.
Clone NameEP701Y IsotypeIgG
Species ReactivityRat, Human (Does not react with: Mouse) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500-1,000; IHC: 1:50-100; ICC: 50-100; IP: 1:50
Predicted MW Explanation 160kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse

Reference Data

Target NameHomo sapiens adenomatous polyposis coli (APC), transcript variant 3
Alternative NameBTPS2; DP2; DP2.5; DP3; GS; PPP1R46
Database LinkNP_000029
Entrez Gene 324 Human
Entrez Gene 24205 Rat
FunctionThis gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq].
Related PathwayDruggable Genome Wnt signaling pathwayRegulation of actin cytoskeletonPathways in cancerColorectal cancerEndometrial cancerBasal cell carcinomaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - APC antibody [EP701Y]; Anti-APC antibody [EP701Y] at 1/1000 dilution + 10 ug/ml HEK293 cell lysate.Secondary.1:2000 goat anti-rabbit HRP labeled .Observed band size : 160 kDa .Additional bands at : 250 kDa. We are unsure as to the identity of these extra bands.

IHC Image
Immunohistochemistry (Paraffin-embedded sections) - APC antibody [EP701Y]; TA303394 (1:50), staining human colon carcinoma by immunohistochemistry, paraffin-embedded tissue.


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