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Anti-AKT1 Antibody E45W
Also for AKT1 (NM_001014432)
|A synthetic peptide corresponding to residues surrounding Ser473 of human Akt1 was used as immunogen. The antibody can detects Akt1 and Akt3. Predicted to cross-react with mouse, rat and bovine, based on sequence homology.|
||Lot dependent; please refer to CoA along with shipment
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 2|
|AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA|
Entrez Gene 207 Human
|The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. |
|Protein KinaseES Cell Differentiation/IPSDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwaymTOR signaling pathwayApoptosisVEGF signaling pathwayMore Pathways >> |
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Western blot - AKT1 antibody [E45W]; Anti-AKT1 antibody [E45W] at 1/10000 dilution + NIH 3T3 cell lysate.Predicted band size : 56 kDa.Observed band size : 60 kDa .