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Anti-AKT1 Antibody Y89
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Also for AKT1 (NM_001014432)
|A synthetic peptide corresponding to residues in C-terminus of human Akt1 was used as immunogen. Predicted to cross-react with mouse, rat and bovine, based on sequence homology.|
|Human, Mouse, Rat
||WB: 1:5,000-10,000; IHC: 1:100; ICC: 1:100-1:250; FC: 1:20; IP: 1:100
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 2|
|AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA|
|The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. |
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
MAPK signaling pathway
Signaling by GPCR
Toll-like receptor signaling pathway
Wnt Signaling Pathway
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Western blot analysis on MCF-7 cell lysate using anti- Akt1/PKBa (C-term) RabMAb (TA303387); dilution 1:10,000.
Immunohistochemical analysis of paraffin-embedded prostate carcinoma using anti-Akt1/PKBa (C-term) RabMAb (TA303387).