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Also for FGFR2 (NM_000141)
|Peptide with sequence C-GREKEITASPDY, from the internal region of the protein sequence according to NP_000132.1; NP_075259.2.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig, Cow
||ELISA: 1:64,000. WB: 0.3-1µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1|
|BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25|
Entrez Gene 2263 Human
Entrez Gene 14183 Mouse
Entrez Gene 25022 Rat
Entrez Gene 415125 Dog
|The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq].|
|Protein KinaseSecreted ProteinTransmembraneDruggable Genome MAPK signaling pathwayEndocytosisRegulation of actin cytoskeletonPathways in cancerProstate cancer|
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TA303352 (0.3µg/ml) staining of A549 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.