Home Antibody All anti-RPE65 antibodies
Also for RPE65 (NM_053562)
| Peptide with sequence C-EVKKNARKAPQPE, from the internal region of the protein sequence according to NP_000320.1.|
|Test: Rat. Expected from seq similarity: Human, Rat, Dog
||ELISA: 1:32,000. WB: 0.5-1.5µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Rattus norvegicus retinal pigment epithelium 65 (Rpe65)|
Entrez Gene 6121 Human
Entrez Gene 89826 Rat
Entrez Gene 403803 Dog
|This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq]. |
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TA303335 (0.5µg/ml) staining of Rat Retina lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.