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Home Antibody All anti-ACVR1 antibodies

Anti-ACVR1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303310
  • Goat Polyclonal Antibody against ACVR1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420209) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for ACVR1 (NM_001105)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen Peptide with sequence C-RKFKRRNQERLNPRD, from the internal region of the protein sequence according to NP_001096.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human. Expected from seq similarity: Human, Mouse, Rat, Dog Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:128,000. WB: 0.3-1µg/ml.
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens activin A receptor, type I (ACVR1), transcript variant 1
Alternative NameACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
Database LinkNP_001096
Entrez Gene 90 Human
Entrez Gene 11477 Mouse
Entrez Gene 79558 Rat
Entrez Gene 478757 Dog
FunctionActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq].
Related PathwayProtein KinaseES Cell Differentiation/IPSTransmembraneDruggable Genome Cytokine-cytokine receptor interactionTGF-beta signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
TA303310 (0.3µg/ml) staining of Human Umbilical Cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

 

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