Home Antibody All anti-PTCH antibodies
Also for PTCH (NM_000264)
| Peptide with sequence C-HPESRHHPPSNPRQQ, from the internal region of the protein sequence according to NP_000255.1.|
|Test: Human, Mouse. Expected from seq similarity: Human, Dog, Pig, Cow
||ELISA: 1:32,000. WB: 1-3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens patched 1 (PTCH1), transcript variant 1b|
|BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11|
Entrez Gene 5727 Human
Entrez Gene 19206 Mouse
Entrez Gene 484137 Dog
|This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq]. |
|ES Cell Differentiation/IPSTransmembraneDruggable Genome Hedgehog signaling pathwayPathways in cancerBasal cell carcinoma|
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TA303124 (1µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.