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Home Antibody All anti-HGS antibodies

Anti-HGS Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303100
  • Goat Polyclonal Antibody against HGS
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401488) , 20ug Explanation
100ug 325 3-7 Days
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IHC(1)
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Also for HGS (NM_004712)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen Peptide with sequence C-NRNYWEKKQEEARK, from the internal region of the protein sequence according to NP_004703.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human. Expected from seq similarity: Human, Mouse, Rat, Dog Concentration0.5 mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:32,000. WB: 1-2µg/ml.
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)
Alternative NameHRS
Database LinkNP_004703
Entrez Gene 9146 Human
Entrez Gene 15239 Mouse
Entrez Gene 56084 Rat
Entrez Gene 483367 Dog
FunctionInvolved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex
Related PathwayDruggable Genome Endocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
TA303100 (2.5µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

 

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