Home Antibody All anti-RGS14 antibodies
Also for RGS14 (NM_006480)
| Peptide with sequence C-IGGSLNSTTDSAL, from the C Terminus of the protein sequence according to NP_006471.|
|Test: Human. Expected from seq similarity: Human
||ELISA: 1:16,000. WB: 0.5-2µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens regulator of G-protein signaling 14 (RGS14)|
|regulator of G-protein signalling 14; regulator of G-protein signaling 14|
Entrez Gene 10636 Human
|This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. COMPLETENESS: complete on the 3' end. |
|Druggable Genome |
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
TA302943 staining (0.5µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.