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Home Antibody All anti-KPNA2 antibodies

Anti-KPNA2 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA302917 Goat Polyclonal Antibody against KPNA2 100ug $325 3-7 Days
LC419418 KPNA2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

Immunogen Peptide with sequence C-QVQDGAPGTFNF, from the C Terminus of the protein sequence according to NP_002257.1.
Clone Name IsotypeGoat IgG
Species ReactivityTested: Human. Expected from sequence similarity: Human, Mouse, Rat, Dog Concentration0.5 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB: 1-3 µg/ml
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)
Alternative NameIPOA1; QIP2; RCH1; SRP1alpha
Database LinkNP_002257
Entrez Gene 3838 Human
Entrez Gene 16647 Mouse
Entrez Gene 85245 Rat
Entrez Gene 480469 Dog
FunctionThe import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq].
Related PathwayStem cell - PluripotencyDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
TA302917 staining (0.1 ug/ml) of Hela lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

IF Image
TA302917 staining (top panel and green) of 4% formaldahyde-fixed HeLa with endogenously expressed HistonH2B-GFP fusion as DNA marker (mid panel and red).


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