Home Antibody All anti-DUSP1 antibodies
Also for DUSP1 (NM_004417)
| Peptide with sequence SYLQSPITTSPSC, from the C Terminus of the protein sequence according to NP_004408.|
|Test: Human, Mouse, Rat. Expected from seq similarity: Human, Mouse, Rat, Dog, Cow
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens dual specificity phosphatase 1 (DUSP1)|
|CL100; HVH1; MKP-1; MKP1; PTPN10|
Entrez Gene 1843 Human
Entrez Gene 19252 Mouse
Entrez Gene 114856 Rat
Entrez Gene 489117 Dog
|The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq]. |
|PhosphataseDruggable Genome MAPK signaling pathway|
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TA302731 staining (2µg/ml) of HeLa lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.