Home Antibody All anti-DDB1 antibodies
Also for DDB1 (NM_001923)
| Peptide with sequence C-DLIKVVEELTRIH, from the C Terminus of the protein sequence according to NP_001914.|
|Test: Human, Mouse. Expected from seq similarity: Human, Mouse, Rat, Dog, Cow
||WB: 0.2-1 µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens damage-specific DNA binding protein 1, 127kDa (DDB1)|
|DDBA; UV-DDB1; XAP1; XPCE; XPE; XPE-BF|
Entrez Gene 1642 Human
Entrez Gene 13194 Mouse
Entrez Gene 64470 Rat
Entrez Gene 476067 Dog
|This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. [provided by RefSeq]. |
|Druggable Genome Nucleotide excision repairUbiquitin mediated proteolysis|
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TA302707 (1 µg/ml) staining of NSO lysate (1E5 cells per lane). Detected by western blot using chemiluminescence.