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Anti-LAT Antibody

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SKU Description Amount Price Availability*  
TA302672 Goat Polyclonal Antibody against LAT1 100ug $325 In Stock
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WB(1)

OriGene Data

Immunogen Peptide with sequence C-GAPDYENLQELN, from the C Terminus of the protein sequence according to NP_055202.1; NP_001014987.1; NP_001014989.1; NP_001014988.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human, Mouse, Rat. Expected from seq similarity: Human, Mouse, Rat Concentration0.5mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:2,000. WB: 1-3µg/ml.
Predicted MW Explanation 27.7 kDa
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Reference Data

Target NameHomo sapiens linker for activation of T cells (LAT), transcript variant 1
Alternative NameLAT1; pp36
Database LinkNP_055202
Entrez Gene 27040 Human
Entrez Gene 16797 Mouse
Entrez Gene 81511 Rat
FunctionThe protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Related PathwayTransmembraneDruggable Genome Natural killer cell mediated cytotoxicityT cell receptor signaling pathwayFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

TA302672 (0.01µg/ml) staining of peripheral blood mononucleocytes lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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