Home Antibody All anti-BLNK antibodies
Also for BLNK (NM_013314)
| Peptide with sequence C-KDSTRLKYAVKVS, from the C Terminus of the protein sequence according to NP_037446.1.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig, Cow
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens B-cell linker (BLNK), transcript variant 1|
|AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65|
Entrez Gene 29760 Human
Entrez Gene 17060 Mouse
Entrez Gene 499356 Rat
Entrez Gene 486814 Dog
|This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
|Druggable Genome B cell receptor signaling pathwayPrimary immunodeficiency|
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TA302649 staining (4µg/ml) of Daudi lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.