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Home Antibody All anti-SOCS3 antibodies

Anti-SOCS3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302617
  • Goat Polyclonal Antibody against SOCS3
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401300) , 20ug Explanation
100ug 325 In Stock
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WB(1)
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Also for SOCS3 (NM_003955)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPeptide with sequence C-PIREFLDQYDAPL, from the C Terminus of the protein sequence according to NP_003946.3.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig, Cow Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 4-6µg/ml.
Predicted MW Explanation 28394Da
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Reference Data

Target NameHomo sapiens suppressor of cytokine signaling 3 (SOCS3)
Alternative NameATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3
Database LinkNP_003946
Entrez Gene 9021 Human
Entrez Gene 12702 Mouse
Entrez Gene 89829 Rat
Entrez Gene 442949 Dog
FunctionThis gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq].
Related PathwayDruggable Genome Ubiquitin mediated proteolysisJak-STAT signaling pathwayInsulin signaling pathwayAdipocytokine signaling pathwayType II diabetes mellitus

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
TA302617 staining (5µg/ml) of MOLT-4 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

 

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