Home Antibody All anti-PPARD antibodies
Also for PPARD (NM_006238)
|Peptide with sequence CHPLLQEIYKDMY, from the C Terminus of the protein sequence according to NP_006229.1.|
|Test: Human, Rat. Expected from seq similarity: Human, Mouse, Rat, Pig, Cow
||ELISA: 1:16,000. WB: 0.3-1µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens peroxisome proliferator-activated receptor delta (PPARD), transcript variant 1|
|FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB|
Entrez Gene 5467 Human
Entrez Gene 19015 Mouse
Entrez Gene 25682 Rat
|This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq]. |
|Nuclear Hormone ReceptorTranscription FactorsDruggable Genome PPAR signaling pathwayWnt signaling pathwayPathways in cancerAcute myeloid leukemia|
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TA302579 (0.3µg/ml) staining of Jurkat lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.