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Home Antibody All anti-MDM2 antibodies

Anti-MDM2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302536
  • Goat Polyclonal Antibody against MDM2 (isoform)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400855) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenPeptide with sequence C-DELSGERQRKRHKSD, from the internal region of the protein sequence according to NP_002383.2.
Clone Name IsotypeGoat IgG
Species ReactivityHuman, Dog, Cat Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:64,000. WB: 0.3-1.0µg/ml.
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Reference Data

Target NameHomo sapiens MDM2 proto-oncogene, E3 ubiquitin protein ligase (MDM2), transcript variant 1
Alternative NameACTFS; hdm2; HDMX
Database LinkNP_002383
FunctionThis gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq].
Related Pathway
Apoptosis
Cell cycle
Senescence and Autophagy

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WB Image
TA302536 (0.3µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

 

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