Home Antibody All anti-CHRNA4 antibodies
Also for CHRNA4 (NM_000744)
|Peptide with sequence C-HVETRAHAEERLLKK, from the internal region of the protein sequence according to NP_000735.1.|
|Test: Human, Rat. Expected from seq similarity: Human, Mouse, Rat, Dog, Cow
||ELISA: 1:64,000. WB: 1-3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens cholinergic receptor, nicotinic, alpha 4 (neuronal) (CHRNA4), transcript variant 1|
|BFNC; EBN; EBN1; NACHR; NACHRA4; NACRA4|
Entrez Gene 1137 Human
Entrez Gene 11438 Mouse
Entrez Gene 25590 Rat
Entrez Gene 485972 Dog
|This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. [provided by RefSeq]. |
|Ion Channels: Cys-loop ReceptorsTransmembraneDruggable Genome |
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TA302451 (0.3µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.