Home Antibody All anti-CYP17A1 antibodies
Also for CYP17A1 (NM_000102)
|Peptide with sequence C-LFKDGDQKLEK, from the internal region of the protein sequence according to NP_000093.1.|
|Test: Human. Expected from seq similarity: Human, Cat, Dog
||ELISA: 1:64,000. WB: 0.1-0.3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1)|
|CPT7; CYP17; P450C17; S17AH|
Entrez Gene 1586 Human
Entrez Gene 477807 Dog
|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq]. |
|P450Druggable Genome C21-Steroid hormone metabolismMetabolic pathways|
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TA302444 (0.3µg/ml) staining of human ovary lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.