Home Antibody All anti-CASP4 antibodies
Also for CASP4 (NM_001225)
|Peptide with sequence CKERAEEIYPIKERN, from the internal region of the protein sequence according to NP_001216; NP_150649; NP_150650.|
|Test: Human. Expected from seq similarity: Human, Mouse, Cat, Dog, Cow
||ELISA: 1:16,000. WB: 0.3-2µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha|
|ICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX|
Entrez Gene 837 Human
Entrez Gene 12363 Mouse
Entrez Gene 403724 Dog
|This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq]. |
|ProteaseDruggable Genome |
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TA302442 (0.3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.