Home Antibody All anti-CACNB4 antibodies
Also for CACNB4 (NM_000726)
|Peptide with sequence CSPGGYSHDSRHRL, from the C Terminus of the protein sequence according to NP_001005747.1; NP_000717.2; NP_001005746.1.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat, Pig
||ELISA: 1:8,000. WB: 0.3-1µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens calcium channel, voltage-dependent, beta 4 subunit (CACNB4), transcript variant 2|
|CAB4; CACNLB4; EA5; EIG9; EJM; EJM4; EJM6|
Entrez Gene 785 Human
Entrez Gene 12298 Mouse
Entrez Gene 58942 Rat
|This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. [provided by RefSeq]. |
|Ion Channels: OtherDruggable Genome MAPK signaling pathwayCardiac muscle contractionHypertrophic cardiomyopathy (HCM)Arrhythmogenic right ventricular cardiomyopathy (ARVC)Dilated cardiomyopathy|
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TA302437 (0.2µg/ml) staining of human bone marrow lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
HEK293 overexpressing CACNB4 (RC210440) and probed with TA302437 (mock transfection in first lane)