Home Antibody All anti-PIK3CG antibodies
Also for PIK3CG (NM_002649)
|This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human PI3KCG.|
||WB: 1: 100~500; IHC: 1: 10~50; ELISA: 1: 1,000;
|Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.|
|Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. (Protein A or G Sepharose)
|Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma (PIK3CG), transcript variant 1|
|p110gamma; p120-PI3K; PI3CG; PI3K; PI3Kgamma; PIK3|
|PIK3CG belongs to the pi3/pi4-kinase family of proteins. It is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene for this protein is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.|
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
Signaling by GPCR
Toll-like receptor signaling pathway
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Western blot analysis of PI3KCG Antibody (Center) Pab (arrow) using purified Pab. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PI3KCG gene (Lane 2) (Origene Technologies).
Formalin-fixed and paraffin-embedded skeletal muscle tissue reacted with PI3KCG antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.