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Home Antibody All anti-PIAS1 antibodies

Anti-PIAS1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302212
  • Rabbit Polyclonal Antibody against PIAS1 (N-term)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402513) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PIAS1.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman Concentration0.25 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 100~500; IHC: 1:50~100; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens protein inhibitor of activated STAT, 1 (PIAS1)
Alternative NameDDXBP1; GBP; GU/RH-II; ZMIZ3
Database LinkNP_057250
FunctionPIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
Related Pathway
Jak-STAT signaling pathway
TGF Beta Signaling Pathway

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WB Image
(LEFT)The PIAS1 polyclonal antibody is used in Western blot to detect PIAS1 in HL-60 tissue lysate. (RIGHT)Western blot analysis of PIAS1 (arrow) using rabbit polyclonal PIAS1 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PIAS1 gene (Lane 2) (Origene Technologies).
IHC Image
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

 

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