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Home Antibody All anti-MAP3K5 antibodies

Anti-MAP3K5 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA302148 Rabbit Polyclonal Antibody against MAP3K5 (S966) 100ug $325 3-7 Days
LC401794 MAP3K5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
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Also for MAP3K5 (NM_005923)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenThis ASK1(MEKK5/MAP3K5) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 944-973 amino acids from human ASK1(MEKK5/MAP3K5).
Clone Name IsotypeRabbit Ig
Species ReactivityHuman (Predicted: Mouse) Concentration0.25 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:1000
Predicted MW Explanation 154537 Da
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Alternative NameASK1; MAPKKK5; MEKK5
Database LinkNP_005914
Entrez Gene 4217 Human
Entrez Gene 26408 Mouse
FunctionMitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayNeurotrophin signaling pathwayAmyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of MAP3K5 (arrow) using rabbit polyclonal MAP3K5 Antibody (Cat.#TA302148).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAP3K5 gene (Lane 2) (Origene Technologies).
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