Homo sapiens TYRO3 protein tyrosine kinase (TYRO3)
Synonyms:
BYK; Dtk; RSE; Sky; Tif
Immunogen
This antibody is generated from rabbits immunized with human recombinant TYRO3 protein.
Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clone Name
Isotype
Rabbit Ig
Species Reactivity
Human
Concentration
0.25 mg/ml
Purification
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. (Protein A or G Sepharose)
Guaranteed Application *
WB
Suggested Dilutions
WB: 1:50~100; ELISA: 1: 1,000;
Background
Tyrosine kinase 3,mainly expressed in brain,is involved in the protection of neurons from apoptosis. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
Related Pathway
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(LEFT) Western blot analysis of anti-TYRO3 Antibody in Hela cell line lysates (35ug/lane).TYRO3(arrow) was detected using the purified Pab (1:60dilution). (RIGHT) Western blot analysis of TYRO3(arrow) using rabbit polyclonal TYRO3 Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TYRO3 gene (Lane 2) (Origene Technologies).
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