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Home Antibody All anti-PRKCB1 antibodies

Anti-PRKCB1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302123
  • Rabbit Polyclonal Antibody against PRKCB1 (C-term)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC419133) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for PRKCB1 (NM_002738)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PKC beta2.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman, Mouse, Rat Concentration0.25 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 100~500; IHC: 1: 10~50; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens protein kinase C, beta (PRKCB), transcript variant 2
Alternative NamePKC-beta; PKCB; PRKCB1; PRKCB2
Database LinkNP_002729
FunctionProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
Hemostasis
MAPK signaling pathway
Melanogenesis
TGF Beta Signaling Pathway
Wnt Signaling Pathway

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WB Image
The anti-PKC beta2 Pab is used in Western blot to detect PKC beta2 in Jurkat cell lysate (lane 1) and mouse brain tissue lysate (lane 2).
IHC Image
Formalin-fixed and paraffin-embedded human brain tissue reacted with PKC beta2 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

 

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