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Home Antibody All anti-MAP2K4 antibodies

Anti-MAP2K4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302111
  • Rabbit Polyclonal Antibody against MAP2K4 (S257)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401058) , 20ug Explanation
100ug 325 3-7 Days
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Also for MAP2K4 (NM_003010)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis MEKK4(MAP2K4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from human MEKK4(MAP2K4).
Clone Name IsotypeRabbit Ig
Species ReactivityHuman (Predicted: Mouse, Xenopus) Concentration0.25 mg/ml
Guaranteed Application * Suggested DilutionsWB: 1:1000, IHC: 1:10~50
Predicted MW Explanation 44288 Da
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase 4 (MAP2K4), transcript variant 1
Alternative NameJNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1
Database LinkNP_003001
Entrez Gene 6416 Human
Entrez Gene 26398 Mouse
FunctionMAP2K4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayToll-like receptor signaling pathwayFc epsilon RI signaling pathwayGnRH signaling pathwayEpithelial cell signaling in Helicobacter pylori infectionMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

 

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