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Home Antibody All anti-FGFR4 antibodies

Anti-FGFR4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302089
  • Mouse Monoclonal Antibody against FGFR4
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400735) , 20ug
100ug 325 3-7 Days
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WB(2)
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Also for FGFR4 (NM_002011)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPurified recombinant FGFR4 fusion protein was used to produced this monoclonal antibody.
Clone Name IsotypeIgG1 Kappa
Species ReactivityHuman Concentration0.25 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:2000; ELISA: 1: 1,000;
BufferPurified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 1
Alternative NameCD334; JTK2; TKF
Database LinkNP_002002
FunctionFGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Related Pathway
MAPK signaling pathway

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WB Image
Western blot analysis of anti-FGFR4 Monoclonal Antibody (Cat.TA302089) by FGFR4 recombinant protein(Fragment 42KD). FGFR4 protein (arrow) was detected using the purified Mab.
WB Image
Western blot analysis of FGFR4 (arrow) using mouse monoclonal FGFR4 antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR4 gene (Lane 2).

 

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