Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS)
ALPS4; N-ras; NRAS1; NS6
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human NRAS.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. (Protein A or G Sepharose)
Guaranteed Application *
WB: 1:50~100; ELISA: 1: 1,000;
NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).
EGFR1 Signaling Pathway
MAPK signaling pathway
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(LEFT)Western blot analysis of anti-NRAS Antibody (N-term) in CEM cell line lysates (35ug/lane). NRAS(arrow) was detected using the purified Pab. (RIGHT)Western blot analysis of NRAS (arrow) using rabbit polyclonal NRAS Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NRAS gene (Lane 2) (Origene Technologies).
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