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Home Antibody All anti-ASCL1 antibodies

Anti-ASCL1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302030
  • Rabbit Polyclonal Antibody against ASCL1 (N-term)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401374) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for ASCL1 (NM_004316)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Hash1.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 100~500; IHC: 1:50~100; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens achaete-scute family bHLH transcription factor 1 (ASCL1)
Alternative NameASH1; bHLHa46; HASH1; MASH1
Database LinkNP_004307
FunctionACSL1, alternatively titled Hash1 or Mash1, is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.
Related Pathway
Delta-Notch Signaling Pathway

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WB Image
(LEFT)The anti-Hash1 Antibody (N-term) is used in Western blot to detect Hash1 in mouse lung tissue lysate. (RIGHT)Western blot analysis of Hash1 (arrow) using rabbit polyclonal Hash1 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Hash1 gene (Lane 2) (Origene Technologies).
IHC Image
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

 

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