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Home Antibody All anti-CASP3 antibodies

Anti-CASP3 Antibody CPP32 4-1-18

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301776
  • Mouse Monoclonal Antibody against Caspase 3 (CPP32 4-1-18)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403215) , 20ug
200ul 325 In Stock
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WB(1)
IHC(1)
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Also for CASP3 (NM_032991)
cDNA Clone shRNA/siRNA Protein/Lysate Antibody Assay

OriGene Data

ImmunogenFull-length recombinant human Caspase 3 protein.
Clone NameCPP32 4-1-18 IsotypeIgG2a kappa
Species Reactivityhuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500-1: 1000
Buffer0.1% sodium azide
Purification Affinity purified

Reference Data

Target NameHomo sapiens caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant beta
Alternative NameCPP32; CPP32B; SCA-1
Database LinkNP_116786
FunctionCaspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase-9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
Related Pathway
Apoptosis
MAPK signaling pathway

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WB Image
Western blot detection of Capsase (19 and 35 kDa) from HEK293 cell extract. Lanes 1 and 2 contain inactive and active Capsase, respectively
IHC Image
Immunohistochemistry-Paraffin: Caspase 3 Antibody (CPP32 4-1-18) - Rat epithelial cells of the tongue base. Antigen retrieval method: Citrate buffer.

 

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