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Anti-CASP3 Antibody CPP32 4-1-18
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Also for CASP3 (NM_032991)
|Full-length recombinant human Caspase 3 protein.|
||WB: 1:500-1: 1000
|0.1% sodium azide|
|Affinity purified (Protein A or G Sepharose)
|Homo sapiens caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant beta|
|CPP32; CPP32B; SCA-1|
|Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase-9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.|
MAPK signaling pathway
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HEK293T cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY CASP3 (RC204444) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CASP3.
Western blot detection of Capsase (19 and 35 kDa) from HEK293 cell extract. Lanes 1 and 2 contain inactive and active Capsase, respectively