The epitope recognized by this antibody maps to a region between residue 425 and the C-terminus (residue 482) of human Histone Deacetylase 1 using the numbering given in entry NP_004955.2 (GeneID 3065).
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Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
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HEK293T cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY HDAC1 (RC201745) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HDAC1.
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