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Anti-APEX1 Antibody 13B8E5C2
Also for APEX1 (NM_001641)
|A fusion protein construct that contains the N-terminal region of human ACAT1.|
|human, mouse, rat
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1:2000, IHC: 1:5000
|PBS and 0.05% sodium azide|
|Purified human APE/ref protein.
|Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1|
|APE; APE1; APEN; APEX; APX; HAP1; REF1|
Entrez Gene 328 Human
Entrez Gene 11792 Mouse
Entrez Gene 79116 Rat
|The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme functions as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1 alpha, Pax-5, Pax-8 and other transcription factors. APE/ref-1 has also been shown to control p53 activity through redox alteration. APE is linked to apoptosis, associated with thioredoxin, and altered levels of APE/ref-1 have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.|
|Stem cell - PluripotencyTranscription FactorsDruggable Genome Base excision repair|
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Western Blot: APE1 Antibody (13B8E5C2) TA301765 - Ovarian Cancer cell lines.
Immunohistochemistry-Paraffin: APE1 Antibody (13B8E5C2) TA301765 - APE1 antibody was tested in human breast cancer xenograft using DAB with hematoxylin counterstain
Immunocytochemistry/Immunofluorescence: APE1 Antibody (13B8E5C2) TA301765 - Immunocytochemical detection of APE-ref-1 in breast cancer cell line MDS231.