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Home Antibody All anti-APEX1 antibodies

Anti-APEX1 Antibody 13B8E5C2


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA301765 Mouse Monoclonal Antibody against APEX1 (13B8E5C2) 50ul $325 3-7 Days
LC400618 APEX1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for APEX1 (NM_001641)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA fusion protein construct that contains the N-terminal region of human ACAT1.
Clone Name13B8E5C2 IsotypeIgG2b
Species Reactivityhuman, mouse, rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:2000, IHC: 1:5000
BufferPBS and 0.05% sodium azide
Purification Purified human APE/ref protein.

Reference Data

Target NameHomo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1
Alternative NameAPE; APE1; APEN; APEX; APX; HAP1; REF1
Database LinkNP_001632
Entrez Gene 328 Human
Entrez Gene 11792 Mouse
Entrez Gene 79116 Rat
FunctionThe mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme functions as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1 alpha, Pax-5, Pax-8 and other transcription factors. APE/ref-1 has also been shown to control p53 activity through redox alteration. APE is linked to apoptosis, associated with thioredoxin, and altered levels of APE/ref-1 have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome Base excision repair

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western Blot: APE1 Antibody (13B8E5C2) TA301765 - Ovarian Cancer cell lines.

IHC Image
Immunohistochemistry-Paraffin: APE1 Antibody (13B8E5C2) TA301765 - APE1 antibody was tested in human breast cancer xenograft using DAB with hematoxylin counterstain

IF Image
Immunocytochemistry/Immunofluorescence: APE1 Antibody (13B8E5C2) TA301765 - Immunocytochemical detection of APE-ref-1 in breast cancer cell line MDS231.


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