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Home Antibody All anti-APEX1 antibodies

Anti-APEX1 Antibody 13B8E5C2

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301765
  • Mouse Monoclonal Antibody against APEX1 (13B8E5C2)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400618) , 20ug
50ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for APEX1 (NM_001641)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA fusion protein construct that contains the N-terminal region of human ACAT1.
Clone Name13B8E5C2 IsotypeIgG2b
Species Reactivityhuman, mouse, rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:2000, IHC: 1:5000
BufferPBS and 0.05% sodium azide
Purification Purified human APE/ref protein.

Reference Data

Target NameHomo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1
Alternative NameAPE; APE1; APEN; APEX; APX; HAP1; REF1
Database LinkNP_001632
FunctionThe mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme functions as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1 alpha, Pax-5, Pax-8 and other transcription factors. APE/ref-1 has also been shown to control p53 activity through redox alteration. APE is linked to apoptosis, associated with thioredoxin, and altered levels of APE/ref-1 have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.
Related Pathway

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WB Image
Western Blot: APE1 Antibody (13B8E5C2) TA301765 - Ovarian Cancer cell lines.
IHC Image
Immunohistochemistry-Paraffin: APE1 Antibody (13B8E5C2) TA301765 - APE1 antibody was tested in human breast cancer xenograft using DAB with hematoxylin counterstain
IF Image
Immunocytochemistry/Immunofluorescence: APE1 Antibody (13B8E5C2) TA301765 - Immunocytochemical detection of APE-ref-1 in breast cancer cell line MDS231.

 

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