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Home Antibody All anti-KCNK2 antibodies

Anti-KCNK2 Antibody

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SKU Description Amount Price Availability*  
TA301657
  • Rabbit Polyclonal Antibody against TREK 1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415432) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide within the N-terminal region [residues 1-100] of the human TREK 1 protein. [Swiss-Prot# Q9NRT2]
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, bovine Concentration1 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 2 ug/ml
BufferTris-glycine, 150mM NaCl and 0.05% sodium azide
Purification Immunogen affinity purified

Reference Data

Target NameHomo sapiens potassium channel, subfamily K, member 2 (KCNK2), transcript variant 2
Alternative NamehTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK; TREK-1; TREK1
Database LinkNP_055032
Entrez Gene 3776 Human
Entrez Gene 16526 Mouse
FunctionA potential new target for antidepressants. Nature Neuroscience pp 1134-1141. A potassium channel called TREK1 may represent a new target for antidepressant drugs, according to research published in the September issue of Nature Neuroscience. The channel may exert its effects through a signaling pathway in the brain different to that normally targeted by most conventional antidepressants, which are thought to work by increasing the level of the neurotransmitter serotonin in the brain. Michel Lazdunski and colleagues studied mice lacking the gene for the TREK1 channel, which normally contributes to the background currents that set the resting membrane potential of neurons. In several behavioral tests used to model depression, these mice behaved as if they had been treated with an antidepressant. In addition, they had increased serotonergic activity, and did not release as much of the stress hormone corticosterone as normal mice in response to mild stress. Moreover, the authors report that the TREK1 channel was also directly inhibited by conventional antidepressants. The finding that mice lacking the gene for TREK1 behave as if they have been given an antidepressant suggests that small molecule 'blockers' of the potassium channel might be effective therapeutically. If TREK1 is found to exert its antidepressant effects through a pathway independent of serotonin, it is possible that future therapies targeting TREK1 channels may be faster acting and may have fewer side effects than conventional antidepressants. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype pp. 1134-1141. Heurteaux C, Lucas G, Guy N, El Yacoubi M, Thummler S, Peng XD, Noble F, Blondeau N, Widmann C, Borsotto M, Gobbi G, Vaugeois JM, Debonnel G, Lazdunski M. Published online: 13 Aug 2006 | doi:10.1038/nn1749 TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fat
Related PathwayIon Channels: PotassiumTransmembraneDruggable Genome

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WB Image
Detection of TREK 1 in human brain membrane lysate

 

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