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Home Antibody All anti-KIAA1524 antibodies

Anti-KIAA1524 Antibody 2G10


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SKU Description Amount Price Availability*  
TA301640 Mouse Monoclonal Antibody against CIP2A (2G10) 100ul $325 In Stock
LC412250 KIAA1524 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for KIAA1524 (NM_020890)
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OriGene Data

ImmunogenA C-terminal portion of the human p90 protein.
Clone Name2G10 IsotypeIgG2b kappa
Species Reactivityhuman Concentration1.8mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5 ug/ml, IF: 1: 100
BufferTris-glycine, 150mM NaCl and 0.05% sodium azide
Purification protein G purified

Reference Data

Target NameHomo sapiens KIAA1524 (KIAA1524)
Alternative NameCIP2A; p90
Database LinkNP_065941
Entrez Gene 57650 Human
FunctionInhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
Related PathwayDruggable Genome

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WB Image
Detection of CIP2A in HeLa whole cell lysate


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