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Home Antibody All anti-LPIN1 antibodies

Anti-LPIN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301605
  • Rabbit Polyclonal Antibody against LPIN1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC407897) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for LPIN1 (NM_145693)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide to an internal region (within residues 300-400) of the human LPIN1 protein. [Swiss-Prot# Q14693]
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat Concentration0.8 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 1000
BufferPBS + 30% glycerol and 0.1% sodium azide
Purification peptide affinity purified

Reference Data

Target NameHomo sapiens lipin 1 (LPIN1), transcript variant 1
Alternative NamePAP1
Database LinkNP_663731
FunctionThe Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1á target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARá. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Related Pathway
Adipogenesis

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WB Image
Detection of LPIN1 in 3T3 L1 lysate
IHC Image
Staining of LPIN1 in mouse pancreas

 

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