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Anti-APOA5 Antibody 1G5G9
Also for APOA5 (NM_052968)
|Ni-NTA purified full-length recombinant human APOA5 expressed in E. Coli strain BL21 (DE3).|
|Homo sapiens apolipoprotein A-V (APOA5), transcript variant 1|
Entrez Gene 116519 Human
|Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four-fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-4 (PPAR-alpha) agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentrations than other apolipoproteins.|
|Secreted ProteinDruggable Genome PPAR signaling pathway|
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Western blot analysis using anti- human APOA5 monoclonal antibody against human serum total protein (lane 2). Lane 1 is a MW standard
Western Blot: Apolipoprotein A5 Antibody (1G5G9) - Detection of Apo A5 in HepG2 cell lysate.