Home Antibody All anti-HIF1AN antibodies
Also for HIF1AN (NM_017902)
|A C-terminal region synthetic peptide made to the human FIH protein sequence (between residues 300 and the C-terminus).|
||WB: 1: 1000-1:5000
|Tris-citrate/phosphate [pH 7-8] buffer. and 0.1% Sodium Azide|
|Immunogen affinity purified
|Homo sapiens hypoxia inducible factor 1, alpha subunit inhibitor (HIF1AN)|
|Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration.|
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Detection of FIH-1 in rat and human samples
Detection of FIH-1 in rat brain tissue (1:100).