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OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [anti-DDK]
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780. [SARM1]
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052 [anti-DDK]
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]
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 Home All anti-HIF1AN antibodies

Anti-HIF1AN Antibody

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SKU Description Amount Price Availability*  
TA301533
  • Rabbit Polyclonal Antibody against Factor Inhibiting HIF-1
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402628) , 20ug
 100ul $325 In Stock Add to Shopping Cart
WB(2)
IHC(1)
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Also for HIF1AN (NM_017902)
cDNA Clone shRNA/siRNA Lysate Protein Antibody
Gene NameHomo sapiens hypoxia inducible factor 1, alpha subunit inhibitor (HIF1AN)
Synonyms:FIH1
ImmunogenA C-terminal region synthetic peptide made to the human FIH protein sequence (between residues 300 and the C-terminus).
BufferTris-citrate/phosphate [pH 7-8] buffer. and 0.1% Sodium Azide
Clone Name Isotype
Species Reactivityhuman, rat Concentration1.25 mg/ml
Purification Immunogen affinity purified (Protein A or G Sepharose)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 1000-1:5000
BackgroundFactor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration.
Related Pathway

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WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY HIF1AN (RC202843) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HIF1AN.
WB Image
Detection of FIH-1 in rat and human samples
IHC Image
Detection of FIH-1 in rat brain tissue (1:100).

 

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