Home Antibody All anti-BBC3 antibodies
Also for BBC3 (NM_014417)
|A synthetic peptide made to a region within the C-terminus of the human PUMA protein sequence (between residues 150-193).|
||WB: 2-4 ug/ml
|Tris-glycine, 150 mM NaCl, 0.05% sodium azide|
|Immunogen affinity purified
|Homo sapiens BCL2 binding component 3 (BBC3), transcript variant 4|
|JFY-1; JFY1; PUMA|
Entrez Gene 27113 Human
|A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.|
|Druggable Genome p53 signaling pathwayHuntington's disease|
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Detection of the beta isoform of PUMA in HL-60 whole cell lysate (4 ug/ml). ECL detection at a 30 minute exposure.